Wertz X., Schoevaert D., Maitournam H., Chassignet P., Schwartz L.

he effect of hormones on bone growth is mediated through mechanical stresses

Mechanical constraints play a key role in regulating cell growth and differentiation. Using data mechanical data available in the literature, we are able to reconstruct a normal growth curve of a child. It appears likely that the impact of hormones on pubertal growth rate sprout followed by growth arrest, can be explained solely by increased mechanical constraints. The uptake of hormones by the muscles results in increased mechanical stresses on the chondrocyte before and at puberty, resulting growth sprout followed by growth cessation.